4.D.1.1.13
Glycosyltransferase (Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase) of 322 aas with 2-3 C-terminal TMSs, ArnC. Catalyzes the transfer of
4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The
modified arabinose is attached to lipid A and is required for resistance
to polymyxin and cationic antimicrobial peptides (Breazeale et al. 2002). This protein does not catalyze transport and is homologous to other enzymes in the GT2 family only in the N-terminal cytoplasmic glycosyl transferase domain.
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| Accession Number: | P77757 |
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| Protein Name: | Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase |
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| Length: | 322 |
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| Molecular Weight: | 36339.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MFEIHPVKKV SVVIPVYNEQ ESLPELIRRT TTACESLGKE YEILLIDDGS SDNSAHMLVE
61: ASQAENSHIV SILLNRNYGQ HSAIMAGFSH VTGDLIITLD ADLQNPPEEI PRLVAKADEG
121: YDVVGTVRQN RQDSWFRKTA SKMINRLIQR TTGKAMGDYG CMLRAYRRHI VDAMLHCHER
181: STFIPILANI FARRAIEIPV HHAEREFGES KYSFMRLINL MYDLVTCLTT TPLRMLSLLG
241: SIIAIGGFSI AVLLVILRLT FGPQWAAEGV FMLFAVLFTF IGAQFIGMGL LGEYIGRIYT
301: DVRARPRYFV QQVIRPSSKE NE