TCDB is operated by the Saier Lab Bioinformatics Group

Pentameric transmembrane electron flow carrier complex, TmcA2BCD.  TmcA is an acidic periplasmic cytochrome c3 of 126 aas and 0 TMSs anchored  to TmcC, TmcB is a ferridoxin/4Fe4S complex protein of 439 aas and 0 TMSs on the cytoplasmic side of the membrane, TmcC is a transmembrane protein of 219 aas and 5 TMSs, and TmcD is a cytochrome protein of 408 aas and 0 TMSs anchored to TmcC on the cytoplasmic side of the membrane.  This complex trasfers electrons resulting from the periplasmic oxidation of H2 to the cytoplasmic reduction of sulfate (Pereira et al. 2006). TmcA shows weak similarity to a constituent of 5.B.3.1.1, TmcB shows similarity to a constituent of 3.D.7.1.1 and TmcC shows weak similarity to a constituent of 5.A.3.1.2, but TmcD does not show similarity to consitutents of other systems in TCDB.

TmcABCD of Desulfovibrio vulgaris

The three component TmcA1B1C1 electron transfer complex from sulfate-reducing bacteria, TmcA1,B1,C1 (Dörries et al. 2016). Transfers electrons from the periplasm to the cytoplasm for sulfate reduction.

TmcA1B1C1 of Desulfococcus multivorans
TmcA1, 132 aas with 1 N-terminal TMS, AOY57579, an acidic cytochrome c.
TmcB1, 445 aas and 0 TMSs, AOY57578, a cytoplasmic iron-sulfur protein
TmcC1, 219 aas and 5 TMSs, AOY57577, an uncharacterized protein of the Tmc complex