5.B.2.2.6
DOMON domain-containing protein FRRS1L precursor of 293 aas and 2 TMSs, one N-terminal and one C-terminal. Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities (Stewart et al. 2019). Alternative splicing of the flip/flop cassette and TARP auxiliary subunits engage in a privileged relationship that fine-tunes AMPA receptor gating (Perozzo et al. 2023).
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| Accession Number: | NP_001136437.1 |
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| Protein Name: | NP_001136437.1 DOMON domain-containing protein FRRS1L precursor [Mus musculus] |
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| Length: | 294 |
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| Molecular Weight: | |
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| Species: | Mus musculus [10090] |
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| Number of TMSs: | 3 |
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| Substrate |
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1: MAGQPLRRPA WVPLLLRLLL AGIAACDASP ADDSAGPGGR GPRGRARGDA GADEAVPRHD
61: SSYGTFASEF YDLRYLSEEG YPFPTAPPVD PFAKIKVEDC GRTKGCFRYG KPGCNAETCD
121: YFLSYRMIGA DVEFELSADT DGWVAVGFSS DKKMGGDDVM ACVHDDNGRV RIQHFYNVGQ
181: WAKEVQRNPA RDEEGVFENN RVTCRFKRPV NVPRDETIVD LHLSWYYLFA WGPAIQGAIT
241: RHDIDSPPAS ERVVSIYKYE DIFMPSAAYQ TFSSPFCLLL IVALTFYLLM GTP