TCDB » SEARCH

« See all members of the family

8.A.1.6.2 The multidrug efflux pump constituent, MdtA [may form a complex with MdtB and MdtC (2.A.6.2.12), both RND proteins. All three proteins appear to be required for resistance (Baranova and Nikaido, 2002).
Accession Number:	P76397
Protein Name:	Multidrug resistance protein MdtA aka MtrA
Length:	415
Molecular Weight:	44464.00
Species:	Escherichia coli (strain K12) [83333]
Number of TMSs:	1
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Peripheral membrane protein²
Substrate

RefSeq:	AP_002674.1 NP_416578.2
Entrez Gene ID:	946604
Pfam:	PF00529
BioCyc:	EcoCyc:MDTA ECOL168927:B2074-MONOMER
KEGG:	ecj:JW5338 eco:b2074
Gene Ontology GO:0005886 C:plasma membrane GO:0008565 F:protein transporter activity GO:0009306 P:protein secretion
References (5) [1] “The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.” Nagakubo S.et.al. 12107133 [2] “A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map.” Itoh T.et.al. 9097040 [3] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [5] “The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate.” Baranova N.et.al. 12107134

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MKGSYKSRWV IVIVVVIAAI AAFWFWQGRN DSRSAAPGAT KQAQQSPAGG RRGMRSGPLA 
61:	PVQAATAVEQ AVPRYLTGLG TITAANTVTV RSRVDGQLIA LHFQEGQQVK AGDLLAEIDP 
121:	SQFKVALAQA QGQLAKDKAT LANARRDLAR YQQLAKTNLV SRQELDAQQA LVSETEGTIK 
181:	ADEASVASAQ LQLDWSRITA PVDGRVGLKQ VDVGNQISSG DTTGIVVITQ THPIDLVFTL 
241:	PESDIATVVQ AQKAGKPLVV EAWDRTNSKK LSEGTLLSLD NQIDATTGTI KVKARFNNQD 
301:	DALFPNQFVN ARMLVDTEQN AVVIPTAALQ MGNEGHFVWV LNSENKVSKH LVTPGIQDSQ 
361:	KVVIRAGISA GDRVVTDGID RLTEGAKVEV VEAQSATTPE EKATSREYAK KGARS

8.A.1.6.2
The multidrug efflux pump constituent, MdtA [may form a complex with MdtB and MdtC (2.A.6.2.12), both RND proteins. All three proteins appear to be required for resistance (Baranova and Nikaido, 2002).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

8.A.1.6.2The multidrug efflux pump constituent, MdtA [may form a complex with MdtB and MdtC (2.A.6.2.12), both RND proteins. All three proteins appear to be required for resistance (Baranova and Nikaido, 2002).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

8.A.1.6.2
The multidrug efflux pump constituent, MdtA [may form a complex with MdtB and MdtC (2.A.6.2.12), both RND proteins. All three proteins appear to be required for resistance (Baranova and Nikaido, 2002).