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8.A.1.7.1 MFP, AaeA, that functions with AaeB, a γ-hydroxybenzoate efflux pump, a member of the Aromatic Acid Exporter Family (TC# 2.A.85) (Van Dyk et al., 2004). Several aromatic carboxylic acids serve as inducers of yhcRQP operon expression.
Accession Number:	P46482
Protein Name:	p-hydroxybenzoic acid efflux pump subunit aaeA
Length:	310
Molecular Weight:	34775.00
Species:	Escherichia coli [83333]
Number of TMSs:	1
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Single-pass membrane protein²
Substrate

DIP:	DIP-12289N
RefSeq:	AP_003783.1 NP_417708.1
Entrez Gene ID:	947748
Pfam:	PF00529
BioCyc:	EcoCyc:G7686-MONOMER ECOL168927:B3241-MONOMER
KEGG:	ecj:JW3210 eco:b3241
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0008565 F:protein transporter activity GO:0046942 P:carboxylic acid transport GO:0009306 P:protein secretion GO:0042221 P:response to chemical stimulus
References (3) [1] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [2] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [3] “Characterization of the Escherichia coli AaeAB efflux pump: a metabolic relief valve?” Van Dyk T.K.et.al. 15489430

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MKTLIRKFSR TAITVVLVIL AFIAIFNAWV YYTESPWTRD ARFSADVVAI APDVSGLITQ 
61:	VNVHDNQLVK KGQILFTIDQ PRYQKALEEA QADVAYYQVL AQEKRQEAGR RNRLGVQAMS 
121:	REEIDQANNV LQTVLHQLAK AQATRDLAKL DLERTVIRAP ADGWVTNLNV YTGEFITRGS 
181:	TAVALVKQNS FYVLAYMEET KLEGVRPGYR AEITPLGSNK VLKGTVDSVA AGVTNASSTR 
241:	DDKGMATIDS NLEWVRLAQR VPVRIRLDNQ QENIWPAGTT ATVVVTGKQD RDESQDSFFR 
301:	KMAHRLREFG

8.A.1.7.1
MFP, AaeA, that functions with AaeB, a γ-hydroxybenzoate efflux pump, a member of the Aromatic Acid Exporter Family (TC# 2.A.85) (Van Dyk et al., 2004). Several aromatic carboxylic acids serve as inducers of yhcRQP operon expression.

Cross database links:

Gene Ontology

References (3)

External Searches:

Analyze:

8.A.1.7.1MFP, AaeA, that functions with AaeB, a γ-hydroxybenzoate efflux pump, a member of the Aromatic Acid Exporter Family (TC# 2.A.85) (Van Dyk et al., 2004). Several aromatic carboxylic acids serve as inducers of yhcRQP operon expression.

Cross database links:

Gene Ontology

References (3)

External Searches:

Analyze:

8.A.1.7.1
MFP, AaeA, that functions with AaeB, a γ-hydroxybenzoate efflux pump, a member of the Aromatic Acid Exporter Family (TC# 2.A.85) (Van Dyk et al., 2004). Several aromatic carboxylic acids serve as inducers of yhcRQP operon expression.