8.A.10.1.1
Slow voltage-dependent K⁺ channel auxiliary protein (β-subunit), MinK or K2NE1. KCNQ1-KCNE1 complexes may interact intermittently with the actin cytoskeleton via the C-terminal region (Mashanov et al., 2010; Coey et al., 2011).  The transmembrane region and the C-terminal cytoplasmic domains that abuts the KCNE1 TMS both interact with and regulate the KCNQ1 channel (Lvov et al. 2010; Zheng et al. 2010). Mutations in KCNE1 can cause Meniere's disease (Doi et al. 2005). MinK-related peptides, MiRPs, confer changes in Kv channel conductance, gating kinetics and pharmacology, and are fundamental to recapitulation of the properties of some native currents. Inherited mutations in KCNE genes are associated with diseases of cardiac and skeletal muscle as well as the inner ear (McCrossan and Abbott 2004).