8.A.10.1.2
Potassium voltage-gated channel Isk-related family member 1, of 129 aas and one TMS, KCNE1 (Sahu et al. 2015).  Mutations can give rise to hearing disorders including chronic tinitus (Sand et al. 2010).  KCNE proteins modulate both homomeric Kv.2.1 and heteromeric Kv2.1/Kv6.4 channels (David et al. 2015). Slow-activating channel complexes formed by KCNQ1 and KCNE1 are essential for human ventricular myocyte repolarization, while constitutively active KCNQ1-KCNE3 channels are important in the intestine. Inherited sequence variants in human KCNE1 and KCNE3 cause cardiac arrhythmias by different mechanisms (Abbott 2015). KCNE confers pH sensitivity to KCNQ1 (Heitzmann et al. 2007). State-dependent interactions between KCNE1 and KCNQ1 have been demonstrated (Westhoff et al. 2017). KCNE1 and KCNE3 exhibit similar functional properties (Law and Sanders 2019). The proximal C-terminal regions of KCNQ1 and KCNE1 participate in a physical and functional interaction during channel opening that is sensitive to perturbation (Chen et al. 2019).