8.A.10.3.2
Potassium voltage-gated channel subfamily E regulatory subunit 5, KCNE5 of 142 aas and 1 TMS. It is a potassium channel ancillary subunit of that is essential for the generation of some native K+ currents by virtue of the formation of heteromeric ion channel complexes with
voltage-gated potassium (Kv) channel pore-forming alpha subunits. It functions as an inhibitory beta-subunit of the repolarizing cardiac
potassium ion channel KCNQ1 (Angelo et al. 2002).
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| Accession Number: | Q9UJ90 |
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| Protein Name: | Potassium voltage-gated channel subfamily E regulatory beta subunit 5 |
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| Length: | 142 |
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| Molecular Weight: | 14993.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
potassium(1+) |
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1: MNCSESQRLR TLLSRLLLEL HHRGNASGLG AGPRPSMGMG VVPDPFVGRE VTSAKGDDAY
61: LYILLIMIFY ACLAGGLILA YTRSRKLVEA KDEPSQACAE HEWAPGGALT ADAEAAAGSQ
121: AEGRRQLASE GLPALAQGAE RV