8.A.10.3.3
KCNE3 or MinK-related peptide 2 of 103 aas with 1 C-terminal TMS.  It modulates the gating kinetics and enhances stability of the channel complex. It assembles with KCNB1 and modulates its gating characteristics of the delayed rectifier voltage-dependent response (McCrossan et al. 2003). It can associate with KCNC4/Kv3.4 to form the subthreshold voltage-gated potassium channel in skeletal muscle and establish the resting membrane potential in muscle cells. Its association with KCNQ1/KCLQT1 may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship (Schroeder et al. 2000). Campbell et al. 2022 provided guidelines for detailed structural studies of KCNE3 in a native membrane environment, comparing lipid bilayer results to the isotropic bicelle structure and to the KCNQ1-bound cryo-EM structure. It has been implicated in autism spectrum disease (Ben-Mahmoud et al. 2024).