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8.A.10.4.1
MinK-related peptide 3 (MiRK3) or KCNE4 (β-subunit) of 170 aas with 1 TMS at about residue 50.  KCNE4 is a crucial host factor for Orf virus infection by mediating viral entry (Sun et al. 2024).  KCNE4 has been shown to consist of extracellular, transmembrane, and intracellular functional regions (Bates et al. 2025).  While the COOH-terminus of KCNE4 physically interacts with the Kv1.3 channel, its transmembrane domain shapes the inactivation properties of the functional complex, fine-tuning the Kv1.3-dependent physiological response in leukocytes (Sastre et al. 2024).

Accession Number:Q9WTW3
Protein Name:KCNE4 aka MinK-related peptide 3
Length:170
Molecular Weight:18639.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Membrane1 / Single-pass type I membrane protein2
Substrate

Cross database links:

RefSeq: NP_067317.1   
Entrez Gene ID: 57814   
Pfam: PF02060   
KEGG: mmu:57814   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005249 F:voltage-gated potassium channel activity
GO:0006813 P:potassium ion transport

References (1)

[1] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLRMEPLNST YPSAAASSSP LESHVPSNSS GNGNEYFYIL VVMSFYGVFL IGIMLGYMKS 
61:	KRREKKSSLL LLYKDEERLW GEAMKPLPMM SGLRSGQVPM MLNMLQESVA PALSCTLCSM 
121:	EGDSVSSESS SPDVHLPIQE EGADDELEET SETPLNDSSE GSSENIHQNS