8.A.104.1.12
Calcium/calmodulin-dependent protein kinase type II, subunit gamma, CAMK2G, of 558 aas and 1 - 3 TMSs. It functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca2+ transport in skeletal muscle and slow twitch muscle (Rose et al. 2006). In fast-twitch muscle, it participates in the control of Ca2+ release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (TC# 8.A.28.1.3) (Proietti Onori et al. 2018).
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| Accession Number: | Q13555 |
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| Protein Name: | Calcium/calmodulin-dependent protein kinase type II subunit gamma |
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| Length: | 558 |
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| Molecular Weight: | 62607.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Sarcoplasmic reticulum membrane1 / Peripheral membrane protein2 / Cytoplasmic side3 |
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| Substrate |
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1: MATTATCTRF TDDYQLFEEL GKGAFSVVRR CVKKTSTQEY AAKIINTKKL SARDHQKLER
61: EARICRLLKH PNIVRLHDSI SEEGFHYLVF DLVTGGELFE DIVAREYYSE ADASHCIHQI
121: LESVNHIHQH DIVHRDLKPE NLLLASKCKG AAVKLADFGL AIEVQGEQQA WFGFAGTPGY
181: LSPEVLRKDP YGKPVDIWAC GVILYILLVG YPPFWDEDQH KLYQQIKAGA YDFPSPEWDT
241: VTPEAKNLIN QMLTINPAKR ITADQALKHP WVCQRSTVAS MMHRQETVEC LRKFNARRKL
301: KGAILTTMLV SRNFSAAKSL LNKKSDGGVK KRKSSSSVHL MPQSNNKNSL VSPAQEPAPL
361: QTAMEPQTTV VHNATDGIKG STESCNTTTE DEDLKGRVPE GRSSRDRTAP SAGMQPQPSL
421: CSSAMRKQEI IKITEQLIEA INNGDFEAYT KICDPGLTSF EPEALGNLVE GMDFHKFYFE
481: NLLSKNSKPI HTTILNPHVH VIGEDAACIA YIRLTQYIDG QGRPRTSQSE ETRVWHRRDG
541: KWLNVHYHCS GAPAAPLQ