8.A.104.1.16
Mitochondrial Ser/Thr protein kinase of 581 aas and as many as 6 possible TMSs about equally spaced throughout it's length, PINK1. Abberrant activation of adenine nucleotide
translocase 3 (TC# 2.a.1.75.8) promotes progression and chemoresistance in multiple
myeloma dependent on PINK1 transport (Hu et al. 2025).
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| Accession Number: | Q9BXM7 |
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| Protein Name: | Serine/threonine-protein kinase PINK1, mitochondrial |
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| Length: | 581 |
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| Molecular Weight: | 62769.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Mitochondrion outer membrane1 / Single-pass membrane protein2 |
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| Substrate |
protein |
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1: MAVRQALGRG LQLGRALLLR FTGKPGRAYG LGRPGPAAGC VRGERPGWAA GPGAEPRRVG
61: LGLPNRLRFF RQSVAGLAAR LQRQFVVRAW GCAGPCGRAV FLAFGLGLGL IEEKQAESRR
121: AVSACQEIQA IFTQKSKPGP DPLDTRRLQG FRLEEYLIGQ SIGKGCSAAV YEATMPTLPQ
181: NLEVTKSTGL LPGRGPGTSA PGEGQERAPG APAFPLAIKM MWNISAGSSS EAILNTMSQE
241: LVPASRVALA GEYGAVTYRK SKRGPKQLAP HPNIIRVLRA FTSSVPLLPG ALVDYPDVLP
301: SRLHPEGLGH GRTLFLVMKN YPCTLRQYLC VNTPSPRLAA MMLLQLLEGV DHLVQQGIAH
361: RDLKSDNILV ELDPDGCPWL VIADFGCCLA DESIGLQLPF SSWYVDRGGN GCLMAPEVST
421: ARPGPRAVID YSKADAWAVG AIAYEIFGLV NPFYGQGKAH LESRSYQEAQ LPALPESVPP
481: DVRQLVRALL QREASKRPSA RVAANVLHLS LWGEHILALK NLKLDKMVGW LLQQSAATLL
541: ANRLTEKCCV ETKMKMLFLA NLECETLCQA ALLLCSWRAA L