8.A.104.1.7
SpdA of 270 aas and 4 putative N-terminal TMSs.  SpdA and SpdB (TC#9.B.106.1.3) are encoded on an 11-kbp multicopy plasmid, pSN22, isolated from Streptomyces nigrifaciens SN22. Both are homologous to DUF2637 domain-containing proteins, and both have 4 N-terminal TMSs. This plasmid is self-transmissible (conjugative), is maintained stably in S. lividans, and forms pocks in a wide range of Streptomyces strains.  SpdA and SpdB are involved in pock formation (Kataoka et al. 1991). SpdA may function  in intramycelial plasmid transfer (Mendes et al. 2000). SpdA (this entry) has a 4 TMS 100 residue sequence homologous to the 4 TMSs in TC# 8.A.104.1.8, but lacks the protein kinase domain of the latter. This 4 TMS sequence is not found in other members of this family.  SpdA overlaps protein 8.A.104.1.8 but is not a member of family 8.A.104; it is homologous only in its short C-terminal region.