| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.105.1.1 | Ferrooxidase, Hephaestin, HEPH, of 1158 aas with one C-terminal TMS and possible another TMS near the N-terminus. It oxidizes ferrous ion (II) to ferric ion (III),
and is involved in iron and possibly copper transport and homeostasis. It promotes iron efflux in associated with ferroportin 1 (TC# 2.A.100.1.4) (Vashchenko and MacGillivray 2013). The distribution of HEPH in various tissues has been studied (Ahn et al. 2018). | Eukaryota |
Metazoa, Chordata | Hephaestin of Homo sapiens |
|
8.A.105.1.2 | Ferrooxidase, Ceruoplasmin, of 1065 aas. Ceruloplasmin is a blue, copper-binding (6 atoms per molecule) glycoprotein. It oxidizes Fe2+ to Fe3+ without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Ceruloplasmin overexpression is associated with oncogenic pathways and poorer survival rates in clear-cell renal cell carcinoma (Zhang et al. 2021).
| Eukaryota |
Metazoa, Chordata | Ceruloplasmin of Homo sapiens |
|
8.A.105.1.3 | Zyklopen, or hephaestin-like protein 1 precursor, of 1159 aas. It functions as a ferroxidase and is involved in copper transport and homeostasis (Vashchenko and MacGillivray 2013). | Eukaryota |
Metazoa, Chordata | Zyklopen of Homo sapiens |