8.A.111.1.1
Store operated calcium entry (SOCE)-associated regulatory factor, SARAF, ia of 339 aas with 2 or 3 TMSs. Overexpression of SARAF in the heart prevents cardiac hypertrophy, probably through suppressing the upregulation of STIM1/Orai1 (Dai et al. 2018). TMEM66 attenuates neointimal hyperplasia after carotid artery injury by store operated calcium entry (SOCE) inactivation. It confers vascular protection against balloon injury (Yang et al. 2019). Regulating the activity of the SOCE response via SARAF activity may allow therapeutic strategies for
triple-negative breast cancer (Saldías et al. 2023).
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| Accession Number: | Q96BY9 |
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| Protein Name: | Store-operated calcium entry-associated regulatory factor |
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| Length: | 339 |
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| Molecular Weight: | 36975.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 3 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MAAACGPGAA GYCLLLGLHL FLLTAGPALG WNDPDRMLLR DVKALTLHYD RYTTSRRLDP
61: IPQLKCVGGT AGCDSYTPKV IQCQNKGWDG YDVQWECKTD LDIAYKFGKT VVSCEGYESS
121: EDQYVLRGSC GLEYNLDYTE LGLQKLKESG KQHGFASFSD YYYKWSSADS CNMSGLITIV
181: VLLGIAFVVY KLFLSDGQYS PPPYSEYPPF SHRYQRFTNS AGPPPPGFKS EFTGPQNTGH
241: GATSGFGSAF TGQQGYENSG PGFWTGLGTG GILGYLFGSN RAATPFSDSW YYPSYPPSYP
301: GTWNRAYSPL HGGSGSYSVC SNSDTKTRTA SGYGGTRRR