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8.A.112.2.1
The mitochondrial respiratory supercomplex factor 2 (Rcf2) of 224 aas and 4 apparent TMSs in a 2 + 2 TMS apparent arrangement.  According to Zhou et al. 2018, there is a 5th TMS at the C-terminus, but it is strongly hydrophilic.  See family description for the structure and function of Rcf2. Each Rcf2 monomer in the dimer has two soluble α-helices and five putative transmembrane (TM) α-helices, including an unexpectedly charged TMS at the C terminus, which mediates dimer formation. Inter-monomer salt bridges and hydrogen bondsare poresent at the dimer interface, which stabilize the Rcf2 dimer structure. Possible structural changes upon embedding Rcf2 into a native lipid environment have been proposed (Zhou et al. 2021).

Accession Number:P53721
Protein Name:Respiratory supercomplex factor 2, mitochondrial
Length:224
Molecular Weight:25344.00
Species:Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Multi-pass membrane protein2
Substrate

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Structure:
6T0B   6T15     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKILTQDEIE AHRSHTLKGG IEGALAGFAI SAIIFKVLPR RYPKFKPSTL TWSIKTALWI 
61:	TPPTVLTAIC AEEASNNFDA TMYGSGSSSE DALDEHRRWK SLSTKDKFVE GLSNNKYKII 
121:	TGAWAASLYG SWVIVNKDPI MTKAQKIVQA RMYAQFITVG LLLASVGLSM YENKLHPNKQ 
181:	KVNEMRRWEN ALRVAEEEER LEKEGRRTGY VSNEERINSK IFKS