| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
8.A.113.1.1 | TMEM150c/Tentonin 3 of 249 aas and 6 TMSs. According to Anderson et al. 2018, it reglulates channels such as Piezo 1 and Piezo 2. According to Hong et al. 2017, it has inherent channel activity, but Ojeda-Alonso et al. 2022 could not demonstrate this, Nevertheless, Pak et al. 2024 showed that tentonin 3 is a pore-forming subunit of a slow inactivation mechanosensitive channel. They reported that tentonin 3/TMEM150C (TTN3) confers mechanically activating (MA) currents with slow inactivation kinetics in somato- and barosensory neurons. Thus, purified TTN3 proteins incorporated into the lipid bilayer displayed spontaneous and pressure-sensitive channel currents. These MA currents were conserved across vertebrates and differ from Piezo1 in activation threshold and pharmacological response. Deep neural network structure prediction programs coupled with mutagenetic analysis predicted a rectangular-shaped, tetrameric structure with six transmembrane helices and a pore at the inter-subunit center. The putative pore aligned with two helices of each subunit and had constriction sites whose mutations changed the MA currents. These findings suggest that TTN3 is a pore-forming subunit of a distinct slow inactivation MA channel, potentially possessing a tetrameric structure (Pak et al. 2024). It appears that Tentonin 3 may both modify some channels and be one as well. Kang and Lee 2024 have confirmed the ion channel activity of tentonin and examined its structure.
| Eukaryota |
Metazoa, Chordata | TMEM150c of Homo sapiens |
|
8.A.113.1.2 | TMEM150a of 271 aas and 6 TMSs. Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (Chung et al. 2015). Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns4P) synthesis (Chung et al. 2015). May also play a role in fasting-induced catabolism. | Eukaryota |
Metazoa, Chordata | TMEM150a of Homo sapiens |
|
8.A.113.1.3 | TMEM150b of 233 aas and 6 TMSs. Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux. Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (Mrschtik et al. 2015). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival. | Eukaryota |
Metazoa, Chordata | TMEM150b of Homo sapiens |
|
8.A.113.1.4 | Uncharacterized TMEM150 homologue of 252 aas and 6 TMSs. | Eukaryota |
Metazoa, Platyhelminthes | UP of Schistosoma japonicum (Blood fluke) |
|
8.A.113.1.5 | Uncharacterized DNA damage-regulated autophagy modulator protein 2 of 243 aas and 6 TMSs. | Eukaryota |
Metazoa, Arthropoda | UP of Anoplophora glabripennis (Asian longhorned beetle) |
|
8.A.113.1.6 | Uncharacterized TMEM150b-like protein of 251 aas and 6 TMSs. | Eukaryota |
Metazoa, Chordata | UP of Branchiostoma belcheri (Belcher's lancelet) Isolated from sea water. |
|
8.A.113.1.7 | Uncharacterized protein of 268 aas and 6 TMSs. | Eukaryota |
Metazoa, Nematoda | UP of Pristionchus pacificus (Parasitic nematode) |
|
8.A.113.1.8 | DNA damage-regulated autophagy modulator protein 1, DRAM1, of 238 aas and 6 TMSs. It is found in the membranes of intracellular organelles including lysosomes, the ER and the golgi apparatus. Loss results in golgi fragmentation (Wei et al. 2019). | Eukaryota |
Metazoa, Chordata | DRAM1 of Homo sapiens |
|
8.A.113.1.9 | DRAM2 or TMEM77 of 266 aas and 6 TMSs. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function (El-Asrag et al. 2015). Induces apoptotic cell death when coexpressed with DRAM1 (TC# 8/A/113/1/8) (Park et al. 2009). | Eukaryota |
Metazoa, Chordata | DRAM2 of Homo sapiens |