8.A.116.1.1
The transmembrane inner ear expressed protein, Tmie (153aas; 2 TMSs). Hair cells express two molecularly and functionally
distinct mechanotransduction channels with different subcellular
distributions. One is activated by sound and is responsible for sensory
transduction. This sensory transduction channel is expressed in hair
cell stereocilia, and its activity is affected by mutations in the genes
encoding the transmembrane
proteins TMHS (TC# 1.A.82.1.1), TMIE (this family), TMC1 and TMC2 (family 1.A.17.4) (Wu et al. 2017). The other is the Piezo2 channel (TC# 1.A.75.1.2) (Qiu and Müller 2018).
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| Accession Number: | Q8K467 |
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| Protein Name: | Transmembrane inner ear expressed protein |
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| Length: | 153 |
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| Molecular Weight: | 17027.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 2 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MAGRQHGSGR LWALGGAALG ACLAGVATQL VEPSTAPPKP KPPPLTKETV VFWDMRLWHV
61: VGIFSLFVLS IIITLCCVFN CRVPRTRKEI EARYLQRKAA KMYTDKLETV PPLNELTEIP
121: GEDKKKKKKD SVDTVAIKVE EDEKNEAKKK GEK