8.A.117.1.5
Neuroligin-1 (NGLN1) of 798 aas and 2 TMSs. Iit is involved in cell-cell-interactions by forming
intercellular junctions through binding to beta-neurexins, and it plays a role in the clustering of the GABA(A) receptor Unc-49 at postsynaptic sites in neuromuscular junctions via
interactions with madd-4 and neurexin, nrx-1. It is is thereby required for
normal GABAergic synaptic transmission (Maro et al. 2015, Tu et al. 2015).
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| Accession Number: | Q9XTG1 |
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| Protein Name: | Neuroligin-1 |
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| Length: | 798 |
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| Molecular Weight: | 89018.00 |
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| Species: | Caenorhabditis elegans [6239] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MERIYLLLLL FLPRIRSYDV RSVTTSWGMV RGEVVSPEGD DLPPVAQYLG IPYGVAPTGQ
61: YRFNMAISAA KWTHMPKDAR KVSPVCIQTD MPELSETKAF KHTSAQRFDF NHRLLPHLKK
121: QSEDCLYMNI YVPERLEISR DNYLPVMVIV HGEEYGWGTG NAFNGTTLAA YGHIIVVTLN
181: YRLGVFGFLG RCESSSCSGN SGISDLVSAL TMLNVILPSF GGDSKSVTLA GWGSGASLVS
241: LLMASPLTQP GRRLFRRAIL LDGSALSPWA ISQNPQQYFM QLAEELACAP KNRTSSFNDN
301: VDTIVRCMQV HSSENITKAV LKIDVPTFLS GFAPIVDGQL IPNKPQVSFS TQYGSLFREI
361: DLLVGISSNP SHHMISNEDL KVGISKEKRM RIFRSLVRNL YDFHREEILA SIINEYTDWE
421: NPRDHPKSIR NGVLNALSDV LYTAPLIETL RSHSADEVRK EANTFMFAFA HETRSWSQEQ
481: PNSGIRGSLS GDIVPYIFGY PLAQGDSEER LYSGFNTDDK GISKVMMHYV SNFVKSGDPS
541: KPNPMSKNFP MGDVFHSTAW PQFDQPNREA YLEITDRPRV KNYYRNAQVG FWNNFIPQLH
601: KNGKETEPVG EEHHLLSDHF RKDSYFGKTR HFSSYANLPF PPPPMPPSPP PELTTKPKPS
661: ESPTTLQTTT ESEKAAAGSF TGKALGGVIF IGCGFLIMNV CLLIAVRREW GKKRRNEKKF
721: QLQYQTYNSN HGGGAEQYNS LNSPEPLLSA SHKNSTSMRP AGISPTCPRH GRAALALQNS
781: RGNSLTAAQA PTLEEIQV