8.A.127.1.1
Receptor activity-modifying protein 1, RAMP1, of 148 aas and 1 C-terminal TMS. It is probably truncated by a protease that cleaves off the N-terminal leader sequence (Bomberger et al. 2005). RAMP1 is associated with the calcitonin-like receptor (CLR) and reveals a calcitonin gene-related peptide (CGRP) receptor. The extracellular region of RAMP1 contains six conserved cysteines. Cys-40, 57, 72 and 104 are required the transport of hRAMP1 together with the CLR to the cell surface (Steiner et al. 2003).
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| Accession Number: | O60894 |
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| Protein Name: | Receptor activity-modifying protein 1 |
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| Length: | 148 |
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| Molecular Weight: | 16988.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MARALCRLPR RGLWLLLAHH LFMTTACQEA NYGALLRELC LTQFQVDMEA VGETLWCDWG
61: RTIRSYRELA DCTWHMAEKL GCFWPNAEVD RFFLAVHGRY FRSCPISGRA VRDPPGSILY
121: PFIVVPITVT LLVTALVVWQ SKRTEGIV