8.A.128.1.13 Tyrosine-protein phosphatase non-receptor type 2, PTPT or PTPN2 of 415 aas and 1 C-terminal TMS. It protects intestinal barrier function by restricting epithelial tight junction remodeling (Marchelletta et al. 2021). It plays also an important role in glucose homeostasis.
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Accession Number: | P17706 |
Protein Name: | Tyrosine-protein phosphatase non-receptor type 2 |
Length: | 415 |
Molecular Weight: | 48473.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 2 |
Location1 / Topology2 / Orientation3: |
Nucleus1 |
Substrate |
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1: MPTTIEREFE ELDTQRRWQP LYLEIRNESH DYPHRVAKFP ENRNRNRYRD VSPYDHSRVK
61: LQNAENDYIN ASLVDIEEAQ RSYILTQGPL PNTCCHFWLM VWQQKTKAVV MLNRIVEKES
121: VKCAQYWPTD DQEMLFKETG FSVKLLSEDV KSYYTVHLLQ LENINSGETR TISHFHYTTW
181: PDFGVPESPA SFLNFLFKVR ESGSLNPDHG PAVIHCSAGI GRSGTFSLVD TCLVLMEKGD
241: DINIKQVLLN MRKYRMGLIQ TPDQLRFSYM AIIEGAKCIK GDSSIQKRWK ELSKEDLSPA
301: FDHSPNKIMT EKYNGNRIGL EEEKLTGDRC TGLSSKMQDT MEENSESALR KRIREDRKAT
361: TAQKVQQMKQ RLNENERKRK RWLYWQPILT KMGFMSVILV GAFVGWTLFF QQNAL