8.A.131.1.7
Transmembrane protease serine 11A, TMPRSS11A, ECRG1, HATL1, HESP, a Type II transmembrane serine proteases of 421 aas and one N-terminal TMS.  It may play a role in cellular senescence. Overexpression inhibits cell growth and induces G1 cell cycle arrest. It is expressed on the surface of airway epithelial cells and has been shown to cleave and activate spike proteins of the severe acute respiratory syndrome (SARS), SARS-2 and the Middle East respiratory syndrome (MERS) coronaviruses (CoVs). The activation cleavage of human TMPRSS11A is mediated by autocatalysis, and activation cleavage occurred before the protein reached the cell surface (Zhang et al. 2020). TMPRSS11a is an age-altered, tissue specific regulator of migration and wound healing (Fernandez et al. 2021).