8.A.136.1.1
β-arrestin, ARRB1, ARR1, of 418 aas. It functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. activated GPCR undergoes inactivation or desensitization by phosphorylation and binding of β-arrestin resulting in diminution of downstream signals. The desensitized GPCRs are internalized into endosomes, wherein they undergo dephosphorylation or resensitization by  a protein phosphatase to be recycled back to the cell membrane as a naïve GPCR (Gupta et al. 2018). It also controls the locations and activities of certain transport proteins (see family description).