8.A.136.1.11
Arrestin domain containing protein, ARRDC3, of 414 aas. It is an adapter protein that plays a role in regulating
cell-surface expression of adrenergic receptors and other G
protein-coupled receptors (Patwari et al. 2011, Han et al. 2013). It also plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation, and may recruit NEDD4 to ADRB2 (Nabhan et al. 2010). It also regulates uncoupling protein 1 (Ucp1; TC# 2.A.29.3.2) expression in adipose tissue (Carroll et al. 2017).
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| Accession Number: | Q96B67 |
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| Protein Name: | Arrestin domain-containing protein 3 |
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| Length: | 414 |
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| Molecular Weight: | 46395.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MVLGKVKSLT ISFDCLNDSN VPVYSSGDTV SGRVNLEVTG EIRVKSLKIH ARGHAKVRWT
61: ESRNAGSNTA YTQNYTEEVE YFNHKDILIG HERDDDNSEE GFHTIHSGRH EYAFSFELPQ
121: TPLATSFEGR HGSVRYWVKA ELHRPWLLPV KLKKEFTVFE HIDINTPSLL SPQAGTKEKT
181: LCCWFCTSGP ISLSAKIERK GYTPGESIQI FAEIENCSSR MVVPKAAIYQ TQAFYAKGKM
241: KEVKQLVANL RGESLSSGKT ETWNGKLLKI PPVSPSILDC SIIRVEYSLM VYVDIPGAMD
301: LFLNLPLVIG TIPLHPFGSR TSSVSSQCSM NMNWLSLSLP ERPEAPPSYA EVVTEEQRRN
361: NLAPVSACDD FERALQGPLF AYIQEFRFLP PPLYSEIDPN PDQSADDRPS CPSR