8.A.136.1.12
Pleckstrin homology domain-containing family F member 1, PLEKHF1 oe Phafin2, of 279 aas and 1 or 2 N-terminal TMSs. It may induce apoptosis through the lysosomal-mitochondrial pathway. It also translocates to the lysosome, initiating the permeabilization of lysosomal membrane and resulting in the release of CTSD and CTSL to the cytoplasm. It triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (Chen et al. 2005). JIP4 and Phafin2 are components of a tubular recycling pathway that operates from macropinosomes (Tan et al. 2021).