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8.A.14.1.4 Auxillary β subunit (β3) of voltage-dependent and Ca²⁺ sensitive K⁺ channel (MaxiK; 1.A.1.3.2) (Brenner et al., 2000). 44% identical to TC# 8.A.14.1.3.
Accession Number:	Q9NPA1
Protein Name:	Calcium-activated potassium channel subunit beta 3 aka β3
Length:	279
Molecular Weight:	31604.00
Species:	Homo sapiens (Human) [9606]
Number of TMSs:	2
Location¹ / Topology² / Orientation³:	Membrane¹ / Multi-pass membrane protein²
Substrate

RefSeq:	NP_055222.3 NP_741979.1 NP_741980.1 NP_741981.1
Entrez Gene ID:	27094
Pfam:	PF03185
OMIM:	605222 gene
Gene Ontology GO:0008076 C:voltage-gated potassium channel complex GO:0015269 F:calcium-activated potassium channel activity GO:0015459 F:potassium channel regulator activity GO:0005513 P:detection of calcium ion GO:0006813 P:potassium ion transport GO:0019228 P:regulation of action potential in neuron
References (11) [1] “Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2.” Riazi M.A.et.al. 10585773 [2] “Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4.” Brenner R.et.al. 10692449 [3] “Cloning and functional expression of two families of Beta-subunits of the large conductance calcium-activated potassium channel.” Uebele V.N.et.al. 10766764 [4] “A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.” Meera P.et.al. 10792058 [5] “hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family.” Behrens R.et.al. 10828459 [6] “Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit.” Xia X.-M.et.al. 10864947 [7] “Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade.” Lingle C.J.et.al. 11382808 [8] “Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini.” Zeng X.-H.et.al. 11382809 [9] “Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivation.” Hu S.et.al. 14612589 [10] “Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels.” Zeng X.-H.et.al. 12740608 [11] “New disguises for an old channel: MaxiK channel beta-subunits.” Orio P.et.al. 12136044

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MDFSPSSELG FHFVAFILLT RHRTAFPASG KKRETDYSDG DPLDVHKRLP SSAGEDRAVM 
61:	LGFAMMGFSV LMFFLLGTTI LKPFMLSIQR EESTCTAIHT DIMDDWLDCA FTCGVHCHGQ 
121:	GKYPCLQVFV NLSHPGQKAL LHYNEEAVQI NPKCFYTPKC HQDRNDLLNS ALDIKEFFDH 
181:	KNGTPFSCFY SPASQSEDVI LIKKYDQMAI FHCLFWPSLT LLGGALIVGM VRLTQHLSLL 
241:	CEKYSTVVRD EVGGKVPYIE QHQFKLCIMR RSKGRAEKS

8.A.14.1.4
Auxillary β subunit (β3) of voltage-dependent and Ca²⁺ sensitive K⁺ channel (MaxiK; 1.A.1.3.2) (Brenner et al., 2000). 44% identical to TC# 8.A.14.1.3.

Cross database links:

Gene Ontology

References (11)

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8.A.14.1.4Auxillary β subunit (β3) of voltage-dependent and Ca2+ sensitive K+ channel (MaxiK; 1.A.1.3.2) (Brenner et al., 2000). 44% identical to TC# 8.A.14.1.3.

Cross database links:

Gene Ontology

References (11)

External Searches:

Analyze:

8.A.14.1.4
Auxillary β subunit (β3) of voltage-dependent and Ca²⁺ sensitive K⁺ channel (MaxiK; 1.A.1.3.2) (Brenner et al., 2000). 44% identical to TC# 8.A.14.1.3.