8.A.143.1.1
Transmembrane protein 132A, TMEM132A, of 1032 aas and 2 TMSs, N-terminal and near the C-terminus. It may play a role in embryonic and postnatal
development of the brain. Increased resistance to cell death is induced by
serum starvation in cultured cells. It regulates cAMP-induced GFAP gene
expression via STAT3 phosphorylation (Sanchez-Pulido and Ponting 2018). It may play a role in Lowe syndrome (LS) (Liu et al. 2020Liu et al. 2020).
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| Accession Number: | Q24JP5 |
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| Protein Name: | Transmembrane protein 132A |
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| Length: | 1023 |
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| Molecular Weight: | 110110.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Golgi apparatus membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MCARMAGRTT AAPRGPYGPW LCLLVALALD VVRVDCGQAP LDPVYLPAAL ELLDAPEHFR
61: VQQVGHYPPA NSSLSSRSET FLLLQPWPRA QPLLRASYPP FATQQVVPPR VTEPHQRPVP
121: WDVRAVSVEA AVTPAEPYAR VLFHLKGQDW PPGSGSLPCA RLHATHPAGT AHQACRFQPS
181: LGACVVELEL PSHWFSQAST TRAELAYTLE PAAEGPGGCG SGEENDPGEQ ALPVGGVELR
241: PADPPQYQEV PLDEAVTLRV PDMPVRPGQL FSATLLLRHN FTASLLTLRI KVKKGLHVTA
301: ARPAQPTLWT AKLDRFKGSR HHTTLITCHR AGLTEPDSSP LELSEFLWVD FVVENSTGGG
361: VAVTRPVTWQ LEYPGQAPEA EKDKMVWEIL VSERDIRALI PLAKAEELVN TAPLTGVPQH
421: VPVRLVTVDG GGALVEVTEH VGCESANTQV LQVSEACDAV FVAGKESRGA RGVRVDFWWR
481: RLRASLRLTV WAPLLPLRIE LTDTTLEQVR GWRVPGPAEG PAEPAAEASD EAERRARGCH
541: LQYQRAGVRF LAPFAAHPLD GGRRLTHLLG PDWLLDVSHL VAPHARVLDS RVASLEGGRV
601: VVGREPGVTS IEVRSPLSDS ILGEQALAVT DDKVSVLELR VQPVMGISLT LSRGTAHPGE
661: VTATCWAQSA LPAPKQEVAL SLWLSFSDHT VAPAELYDRR DLGLSVSAEE PGAILPAEEQ
721: GAQLGVVVSG AGAEGLPLHV ALHPPEPCRR GRHRVPLASG TAWLGLPPAS TPAPALPSSP
781: AWSPPATEAT MGGKRQVAGS VGGNTGVRGK FERAEEEARK EETEAREEEE EEEEEMVPAP
841: QHVTELELGM YALLGVFCVA IFIFLVNGVV FVLRYQRKEP PDSATDPTSP QPHNWVWLGT
901: DQEELSRQLD RQSPGPPKGE GSCPCESGGG GEAPTLAPGP PGGTTSSSST LARKEAGGRR
961: KRVEFVTFAP APPAQSPEEP VGAPAVQSIL VAGEEDIRWV CEDMGLKDPE ELRNYMERIR
1021: GSS