8.A.159.1.2
MARCH6 of 910 aas and ~15 TMSs in a 3 + 6 + 6 TMS arrangement. It is a E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation (Hassink et al. 2005). It promotes ubiquitination of DIO2, leading to its degradation (Zavacki et al. 2009) as well as of SQLE, leading to its degradation (Zelcer et al. 2014). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. It may cooperate with UBE2G1 (Hassink et al. 2005). Some members of TC family 3.A.16 (i.e., 3.A.16.1.2 and 1.5) utilize homologues as part of a multicomponent system.