8.A.161.1.1
Alpha/beta hydrolase domain-containing protein 17A, ABHD17a, a thioesterase that hydrolyzes fatty acids from S-acylated cysteine residues in proteins (Lin and Conibear 2015) and has depalmitoylating activity towards NRAS and DLG4/PSD95. Site-specific deacylation by ABHD17a controls BK channel splice variant activities (McClafferty et al. 2020).
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| Accession Number: | Q96GS6 |
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| Protein Name: | Alpha/beta hydrolase domain-containing protein 17A |
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| Length: | 310 |
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| Molecular Weight: | 33990.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Lipid-anchor2 / Cytoplasmic side3 |
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| Substrate |
thiocarboxylic ester |
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1: MNGLSLSELC CLFCCPPCPG RIAAKLAFLP PEATYSLVPE PEPGPGGAGA APLGTLRASS
61: GAPGRWKLHL TERADFQYSQ RELDTIEVFP TKSARGNRVS CMYVRCVPGA RYTVLFSHGN
121: AVDLGQMSSF YIGLGSRLHC NIFSYDYSGY GASSGRPSER NLYADIDAAW QALRTRYGIS
181: PDSIILYGQS IGTVPTVDLA SRYECAAVVL HSPLTSGMRV AFPDTKKTYC FDAFPNIEKV
241: SKITSPVLII HGTEDEVIDF SHGLALYERC PKAVEPLWVE GAGHNDIELY SQYLERLRRF
301: ISQELPSQRA