8.A.192.1.1
DnaJC5 chaparone protein of 198 aas and 1 or 2 adjacent TMSs, including residues 95 - 120. Mutations in DNAJC5/CSPalpha are associated with adult neuronal ceroid lipofuscinosis (ANCL), a dominant-inherited neurodegenerative disease featuring lysosome-derived autofluorescent storage materials (AFSMs) termed lipofuscin. Functionally, DNAJC5 has been implicated in chaperoning synaptic proteins and in misfolding-associated protein secretion (Lee et al. 2022).
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| Accession Number: | P60904 |
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| Protein Name: | DnaJ homolog subfamily C member 5 |
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| Length: | 198 |
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| Molecular Weight: | 22101.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
protein |
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1: MADQRQRSLS TSGESLYHVL GLDKNATSDD IKKSYRKLAL KYHPDKNPDN PEAADKFKEI
61: NNAHAILTDA TKRNIYDKYG SLGLYVAEQF GEENVNTYFV LSSWWAKALF VVCGLLTCCY
121: CCCCLCCCFN CCCGKCKPKA PEGEETEFYV SPEDLEAQLQ SDEREATDTP IVIQPASATE
181: TTQLTADSHP SYHTDGFN