8.A.192.2.1
DnaJ homolog subfamily C, member 13, DnaJC13 or RME8 or RME-8, of 2243 aas and 0 - 7 possible TMSs. It is involved in membrane trafficking through early endosomes, such as the
early endosome to recycling endosome transport implicated in the
recycling of transferrin and the early endosome to late endosome
transport implicated in degradation of EGF and EGFR (Fujibayashi et al. 2008, Girard and McPherson 2008). SNX-1 and the IWN domains control the conformation of RME-8 and hence the productive exposure of the DNAJ domain (Norris et al. 2022).
|
| Accession Number: | NP_001156498.1 |
|---|
| Protein Name: | NP_001156498.1 dnaJ homolog subfamily C member 13 isoform 2 [Mus musculus] |
|---|
| Length: | 2244 |
|---|
| Molecular Weight: | |
|---|
| Species: | Mus musculus [10090] |
|---|
| Substrate |
protein |
|---|
1: MNIIRENKDL ACFYTTKHSW RGKYKRVFSV GTHAVTTYNP NTLEVTNQWP YGDICSISPV
61: GKGQGTEFNL TFRKGSGKKS ETLKFSTEHR TELLTEALRF RTDFAEGKIT GRRYNCYKHH
121: WSDAKKPVVL EVTPGGFDQI NPVTNRVLCS YDYRNIEGFV DLSDYQGGFC ILYGGFSRLH
181: LFSSEQREEI IKSAIEHAGN YIGISLRIRK EPLEFEQYLN LRFGKYSTDE SITSLAEFVV
241: QKISPRHSEP VKRVLAVTET CLVERDPATY NIATLKPLGE VFALVCDSEN PQLFTIEFIK
301: GQVRKYSSTE RDSLLASLLD GVRASGNRDV CVKMAPTHKG QRWGLLSMPI DEEVESLHLR
361: FLAAPPNGNF ADAVFRFNAN ISYSGVLHAV TQDGLFSENK EKLINNAITA LLSQEGDVVA
421: SNAELESQFQ AVRRLVASKA GFLAFTQLPK FRERLGMKVV KALKRSNNGV IHAAVDMLCA
481: LMCPMHDDYD LRQEQLNKAS LLSSKKFLEN LLEKFNSHVD HGTGALVISS LLDFLTFALC
541: APYSETTEGQ QFDMLLEMVA SNGRTLFKLF QHPSMAIVKG AGLVMKAIIE EGDREIATKM
601: QELALSEGAL PRHLHTAMFT ISSDQRMLTN RQLSRHLVGL WTADNTTATN LLKRILPPGL
661: LAYLDSSDPV PEKDADRMHV RDNVKIAMDQ YGKFNKVPEW QRLAGKAAKE VEKFAKEKVD
721: LVLMHWRDRM GIAQKENINQ KPVVLRKRRQ RIKIEANWDL FYYRFSQDHA RSNLIWNFKT
781: REELKDALES EMRTFNIDRE LGSASVISWN HHEFEVKYEC LAEEIKIGDY YLRLLLEEDE
841: NEESGSIKRS YEFFNELYHR FLLTPKVNMK CLCLQALAIV YGRCHEEIGP FTDTRYIIGM
901: LERCTDKLER DRLILFLNKL ILNKKNVKDL MDSNGIRILV DLLTLAHLHV SRATVPLQSN
961: VIEASPDMKR ESEKEWYFGN ADKERSGPYG FHEMQELWAK GMLNAKTRCW AQGMDGWRPL
1021: QAIPQLKWCL LASGQAVLNE TDLATLILNM LITMCGYFPS RDQDNAIIRP LPRVKRLLSD
1081: STCLPHVIQL LLTFDPILVE KVAILLHHIM QDNPQLPRLY LSGVFFFIMM YTGSNVLPVA
1141: RFLKYTHSKQ AFKSEETKGQ DIFQRSILGH ILPEAMVCYL ENYEPEKFSE IFLGEFDTPE
1201: AIWSSEMRRL MIEKIAAHLA DFTPRLQSNT RALYQYCPIP VINYPQLENE LFCNIYYLKQ
1261: LCDTLRFPDW PIKDPVKLLK DSLDAWKKEV EKKPPMMSID DAYEVLNLPI GQGLHDESKI
1321: RKAYFRLAQK YHPDKNPEGR DMFEKVNKAY EFLCTKSTKI VDGPDPENII LILKTQSILF
1381: NRHKEELQPY KYAGYPMLIR TITMETSDDL LFSKESPLLP AAAELAFHTV NCSALNAEEL
1441: RRENGLEVLQ EAFSRCVAVL NRSSKPSDMS VQVCGHISRC YSVAAQFEEC REKITEMPGI
1501: IKDLCRVLYF GKCIPRVAAL AVECVSSFAV DFWLQTHLFQ AGILWYLLVY LFNYDYTLEE
1561: SGIQKNEETN QQEVANSLAK LSVHALSRLG GYLSEDQATP ENPTVRKSLA GMLTPYIARK
1621: LAVASATETL KMLNSNTESP YLMWNNSTRA ELLEFLESQQ ENMIKKGDCD KTYGAEFVYS
1681: EHAKELIVGE IFVRVYNEVP TFQLEVPKEF AASLLDYIGS QAQYLHTFMA ITHAAKVESE
1741: QHGDRLPRVE MALEALRNVI KYNPGSESEC IGHFKLIFSL LRVHGAGQVQ QLALEVVNIV
1801: TSNQDCVNNI AESMVLSNLL ALLHSLPSSR QLVLETLYAL ASNTKIIKEA MAKGALIYLL
1861: DMFCNSTHPQ VRSQTAELFA KMTADKLIGP KVRITLMKFL PSVFMDAMRD NPEAAVHIFE
1921: GTHENPELIW NDSSRDKVST TVREMMLEHF KNQRDNPDVN WKLPEDFAVV FGEAEGELAV
1981: GGVFLRIFIA QPAWVLRKPR EFLIALLEKL TELLEKNNPH GETLETLTMA TVCLFSAQPQ
2041: LADQVPPLGH LPKVIQAMNH RNNAIPKSAI RVIHVLSDNE LCVRAMASLE TIGPLMNGMR
2101: KRADTVGLAC EAINRMFQKE QSELVAQALK AELVPYLLKL LEGVGLENLD SPAATKAQIV
2161: KALKAMTRSL QYGEQVSEIL SRSSVWSAFK DQKHDLFISD SQTAGYLTGP GVAGYLTAGT
2221: SSSAMSNLPP PVDHEAGDLG YQT