8.A.204.1.5
Desmocollin-2, DSC2, of 901 aas with two TMSs, one N-terminal and the other at residue position 710. It is a component of intercellular desmosome junctions and is involved in the
interaction of plaque proteins and intermediate filaments mediating
cell-cell adhesion. It may contribute to epidermal cell positioning
(stratification) by mediating differential adhesiveness between cells
that express different isoforms. It is alterred in amounts following acute kidney injury following Covid-19 infection (Paranjpe et al. 2023). In addition to other members of family 8.A.204, it contains a domain homologous to those in cadherin (TC# 9.A.14.6.4) and protocadherin (TC# 1.A.17.4.13). Cardiomyopathy-related desmocollin-2 prodomain variants affect the intracellular cadherin transport and processing (Pohl et al. 2023).
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| Accession Number: | Q02487 |
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| Protein Name: | Desmocollin-2 |
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| Length: | 901 |
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| Molecular Weight: | 99962.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MEAARPSGSW NGALCRLLLL TLAILIFASD ACKNVTLHVP SKLDAEKLVG RVNLKECFTA
61: ANLIHSSDPD FQILEDGSVY TTNTILLSSE KRSFTILLSN TENQEKKKIF VFLEHQTKVL
121: KKRHTKEKVL RRAKRRWAPI PCSMLENSLG PFPLFLQQVQ SDTAQNYTIY YSIRGPGVDQ
181: EPRNLFYVER DTGNLYCTRP VDREQYESFE IIAFATTPDG YTPELPLPLI IKIEDENDNY
241: PIFTEETYTF TIFENCRVGT TVGQVCATDK DEPDTMHTRL KYSIIGQVPP SPTLFSMHPT
301: TGVITTTSSQ LDRELIDKYQ LKIKVQDMDG QYFGLQTTST CIINIDDVND HLPTFTRTSY
361: VTSVEENTVD VEILRVTVED KDLVNTANWR ANYTILKGNE NGNFKIVTDA KTNEGVLCVV
421: KPLNYEEKQQ MILQIGVVNE APFSREASPR SAMSTATVTV NVEDQDEGPE CNPPIQTVRM
481: KENAEVGTTS NGYKAYDPET RSSSGIRYKK LTDPTGWVTI DENTGSIKVF RSLDREAETI
541: KNGIYNITVL ASDQGGRTCT GTLGIILQDV NDNSPFIPKK TVIICKPTMS SAEIVAVDPD
601: EPIHGPPFDF SLESSTSEVQ RMWRLKAIND TAARLSYQND PPFGSYVVPI TVRDRLGMSS
661: VTSLDVTLCD CITENDCTHR VDPRIGGGGV QLGKWAILAI LLGIALLFCI LFTLVCGASG
721: TSKQPKVIPD DLAQQNLIVS NTEAPGDDKV YSANGFTTQT VGASAQGVCG TVGSGIKNGG
781: QETIEMVKGG HQTSESCRGA GHHHTLDSCR GGHTEVDNCR YTYSEWHSFT QPRLGEKVYL
841: CNQDENHKHA QDYVLTYNYE GRGSVAGSVG CCSERQEEDG LEFLDNLEPK FRTLAEACMK
901: R