8.A.209.1.1
TMEM214 of 689 aas and 1 TMS at about residue 500. It regulates the electrogenic Na⁺-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na⁺ to sugar coupling ratio of 2:1 (see, for example, TC# 2.a.1.7.26) Transport activity by SGLT is driven by a transmembrane Na⁺ electrochemical gradient (the smf) set by the Na⁺/K⁺ pump (Kamitori et al. 2022, Han et al. 2022). It plays a primary role in the transport of dietary monosaccharides from enterocytes to the blood and is responsible for the absorption of D-glucose and D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, SGLT functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (Martín et al. 1996).