8.A.21.2.8
Prohibitin, Phb, of 272 aas and 1 N-terminal TMS. It plays a role in glucose homeostasis in adipose tissue. Expression of its structural gene is affected by emodin which also decreases body weight and blood lipids while increasing glucose tolerance and ceramides (Cheng et al. 2021). Together with PHB2, it forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains IMM mitochondrial integrity. It regulates mitochondrial respiratory activity, playing a role in cellular aging (Coates et al. 2001). Bakuchiol targets prohibitins and mitochondrial proteins including VDACs (Shoji et al. 2024).