8.A.218.1.1
TREM2 of 230 aas and 2 TMSs, N- and C-terminal. It plays a role in frontotemporal dementia (FTD) that is a common cause of presenile dementia and is characterized by behavioural and/or language changes leading to progressive cognitive deficits (Lok and Kwok 2021). A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2 (Karsak et al. 2020).
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| Accession Number: | Q9NZC2 |
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| Protein Name: | Triggering receptor expressed on myeloid cells 2 |
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| Length: | 230 |
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| Molecular Weight: | 25447.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Secreted1 |
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| Substrate |
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1: MEPLRLLILL FVTELSGAHN TTVFQGVAGQ SLQVSCPYDS MKHWGRRKAW CRQLGEKGPC
61: QRVVSTHNLW LLSFLRRWNG STAITDDTLG GTLTITLRNL QPHDAGLYQC QSLHGSEADT
121: LRKVLVEVLA DPLDHRDAGD LWFPGESESF EDAHVEHSIS RSLLEGEIPF PPTSILLLLA
181: CIFLIKILAA SALWAAAWHG QKPGTHPPSE LDCGHDPGYQ LQTLPGLRDT