8.A.227.1.1
The TMEM79 protein in humans, Matt, is of 394 aas with a 200 aa long
N-terminal domain followed by a C-terminal integral membrane domain with
5 putative TMSs. It regulates TRPV3 (TC# 1.A.4.2.9) (Lei et al. 2023) and contributes to epidermal integrity and the skin barrier function. It also plays
roles in the lamellar granule (LG) secretory system and in stratum
corneum (SC) epithelial cell formation. It is involvement of skin TRPV3 temperature detection regulation in mice (Lei et al. 2023).
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| Accession Number: | Q9BSE2 |
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| Protein Name: | Transmembrane protein 79 |
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| Length: | 394 |
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| Molecular Weight: | 43520.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Lysosome1 |
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| Substrate |
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1: MTEQETLALL EVKRSDSPEK SSPQALVPNG RQPEGEGGAE SPGAESLRVG SSAGSPTAIE
61: GAEDGLDSTV SEAATLPWGT GPQPSAPFPD PPGWRDIEPE PPESEPLTKL EELPEDDANL
121: LPEKAARAFV PIDLQCIERQ PQEDLIVRCE AGEGECRTFM PPRVTHPDPT ERKWAEAVVR
181: PPGCSCGGCG SCGDREWLRA VASVGAALIL FPCLLYGAYA FLPFDVPRLP TMSSRLIYTL
241: RCGVFATFPI VLGILVYGLS LLCFSALRPF GEPRREVEIH RRYVAQSVQL FILYFFNLAV
301: LSTYLPQDTL KLLPLLTGLF AVSRLIYWLT FAVGRSFRGF GYGLTFLPLL SMLMWNLYYM
361: FVVEPERMLT ATESRLDYPD HARSASDYRP RPWG