8.A.238.1.3
CED6/GULF of 304 aas. It is a PTB domain-containing engulfment adapter protein 1 that functions as an adapter and is required for efficient phagocytosis
of apoptotic cells. It modulates cellular glycosphingolipid and cholesterol
transport, and may play a role in the internalization and endosomal
trafficking of various LRP1 ligands, such as PSAP (Smits et al. 1999; Liu and Hengartner 1999). CED-6/GULP and components of the
clathrin-mediated endocytosis machinery act redundantly to correctly
display CED-1 on the cell membrane in Caenorhabditis elegans (Harders et al. 2024).
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| Accession Number: | Q9UBP9 |
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| Protein Name: | PTB domain-containing engulfment adapter protein 1 |
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| Length: | 304 |
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| Molecular Weight: | 34490.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MNRAFSRKKD KTWMHTPEAL SKHFIPYNAK FLGSTEVEQP KGTEVVRDAV RKLKFARHIK
61: KSEGQKIPKV ELQISIYGVK ILEPKTKEVQ HNCQLHRISF CADDKTDKRI FTFICKDSES
121: NKHLCYVFDS EKCAEEITLT IGQAFDLAYR KFLESGGKDV ETRKQIAGLQ KRIQDLETEN
181: MELKNKVQDL ENQLRITQVS APPAGSMTPK SPSTDIFDMI PFSPISHQSS MPTRNGTQPP
241: PVPSRSTEIK RDLFGAEPFD PFNCGAADFP PDIQSKLDEM QEGFKMGLTL EGTVFCLDPL
301: DSRC