8.A.24.1.10
Golgi-associated PDZ and coiled-coil motif-containing protein, PIST or GOPC, of 462 aas and 1 possible N-terminal TMS.  The protein plays a role in intracellular protein trafficking and degradation, but also regulates CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (Cheng et al. 2004; He et al. 2004). It also regulates the intracellular trafficking of the ADR1B receptor and plays a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes (Cheng et al. 2002). The retention of Golgi membrane proteins can also be mediated by the Bre5p/Ubp3p deubiquitinase complex (Wang et al. 2020).