8.A.24.1.12
Glutamate receptor-interacting protein 1, GRIP1, of 1128 aas and possibly one C-terminal TMS. It may play a role as a localized scaffold for the
assembly of multiprotein signaling complexes and as a mediator of the
trafficking of its binding partners at specific subcellular location in
neurons (Brückner et al. 1999).
Through complex formation with NSG1, GRIA2 and STX12, it controls the
intracellular fate of AMPAR and the endosomal sorting of the GRIA2
subunit toward recycling and membrane targeting. It regulates the surface expression and synaptic stabilization of AMPARs by direct interaction with several members of the AMPAR family, and thereby regulates synaptic plasticity in learning and memory (Tan et al. 2020).
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| Accession Number: | Q9Y3R0 |
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| Protein Name: | Glutamate receptor-interacting protein 1 |
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| Length: | 1128 |
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| Molecular Weight: | 122422.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasmic vesicle1 |
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| Substrate |
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1: MIAVSFKCRC QILRRLTKDE SPYTKSASQT KPPDGALAVR RQSIPEEFKG STVVELMKKE
61: GTTLGLTVSG GIDKDGKPRV SNLRQGGIAA RSDQLDVGDY IKAVNGINLA KFRHDEIISL
121: LKNVGERVVL EVEYELPPVS VQGSSVIFRT VEVTLHKEGN TFGFVIRGGA HDDRNKSRPV
181: VITCVRPGGP ADREGTIKPG DRLLSVDGIR LLGTTHAEAM SILKQCGQEA ALLIEYDVSV
241: MDSVATASGP LLVEVAKTPG ASLGVALTTS MCCNKQVIVI DKIKSASIAD RCGALHVGDH
301: ILSIDGTSME YCTLAEATQF LANTTDQVKL EILPHHQTRL ALKGPDHVKI QRSDRQLTWD
361: SWASNHSSLH TNHHYNTYHP DHCRVPALTF PKAPPPNSPP ALVSSSFSPT SMSAYSLSSL
421: NMGTLPRSLY STSPRGTMMR RRLKKKDFKS SLSLASSTVG LAGQVVHTET TEVVLTADPV
481: TGFGIQLQGS VFATETLSSP PLISYIEADS PAERCGVLQI GDRVMAINGI PTEDSTFEEA
541: SQLLRDSSIT SKVTLEIEFD VAESVIPSSG TFHVKLPKKH NVELGITISS PSSRKPGDPL
601: VISDIKKGSV AHRTGTLELG DKLLAIDNIR LDNCSMEDAV QILQQCEDLV KLKIRKDEDN
661: SDEQESSGAI IYTVELKRYG GPLGITISGT EEPFDPIIIS SLTKGGLAER TGAIHIGDRI
721: LAINSSSLKG KPLSEAIHLL QMAGETVTLK IKKQTDAQSA SSPKKFPISS HLSDLGDVEE
781: DSSPAQKPGK LSDMYPSTVP SVDSAVDSWD GSAIDTSYGT QGTSFQASGY NFNTYDWRSP
841: KQRGSLSPVT KPRSQTYPDV GLSYEDWDRS TASGFAGAAD SAETEQEENF WSQALEDLET
901: CGQSGILREL EEKADRRVSL RNMTLLATIM SGSTMSLNHE APTPRSQLGR QASFQERSSS
961: RPHYSQTTRS NTLPSDVGRK SVTLRKMKQE IKEIMSPTPV ELHKVTLYKD SDMEDFGFSV
1021: ADGLLEKGVY VKNIRPAGPG DLGGLKPYDR LLQVNHVRTR DFDCCLVVPL IAESGNKLDL
1081: VISRNPLASQ KSIDQQSLPG DWSEQNSAFF QQPSHGGNLE TREPTNTL