8.A.24.1.14
Na+/H+ exchange regulatory cofactor NHE-RF4, NHERF4, of 571 aas. It acts as a regulatory protein that associates with GUCY2C and negatively
modulates its heat-stable enterotoxin-mediated activation (Scott et al. 2002). It stimulates SLC9A3 activity in the presence of elevated calcium ions (Zachos et al. 2008). Catalytic region mimetics in Na+ /H+ exchanger
regulatory factor 4 suppress Guanylate Cyclase 2C activity to regulate
enterotoxin triggered diarrhea (Ramananda et al. 2025).
|
| Accession Number: | Q86UT5 |
|---|
| Protein Name: | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 |
|---|
| Length: | 571 |
|---|
| Molecular Weight: | 61032.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Peripheral membrane protein2 |
|---|
| Substrate |
|
|---|
1: MVTPSPPGNH SLSLEAPRLH TASDLLGNHS LGLPLITALV GSRDRRGRVF SPVPVPLPTN
61: PTTQHPTRQK LPSTLSGHRV CQAHGEPVLG LCPLLPLFCC PPHPPDPWSL ERPRFCLLSK
121: EEGKSFGFHL QQELGRAGHV VCRVDPGTSA QRQGLQEGDR ILAVNNDVVE HEDYAVVVRR
181: IRASSPRVLL TVLARHAHDV ARAQLGEDAH LCPTLGPGVR PRLCHIVKDE GGFGFSVTHG
241: NQGPFWLVLS TGGAAERAGV PPGARLLEVN GVSVEKFTHN QLTRKLWQSG QQVTLLVAGP
301: EVEEQCRQLG LPLAAPLAEG WALPTKPRCL HLEKGPQGFG FLLREEKGLD GRPGQFLWEV
361: DPGLPAKKAG MQAGDRLVAV AGESVEGLGH EETVSRIQGQ GSCVSLTVVD PEADRFFSMV
421: RLSPLLFLEN TEAPASPRGS SSASLVETED PSLEDTSVPS VPLGSRQCFL YPGPGGSYGF
481: RLSCVASGPR LFISQVTPGG SAARAGLQVG DVILEVNGYP VGGQNDLERL QQLPEAEPPL
541: CLKLAARSLR GLEAWIPPGA AEDWALASDL L