8.A.24.1.4
Group II metabotropic glutamate receptor, mGluR2/3, interacting protein, Grip2, of 1043 aas. May play a role as a localized scaffold for
the assembly of multiprotein signaling complexes and as mediator of the
trafficking of its binding partners at specific subcellular locations in
neurons. In mutant mice, the mGluR2/3 agonist, LY379268, restores excitatory and inhibitory defects with similar
efficiency as olanzapine in a two-hit schizophrenia mouse model (Engel et al. 2016).
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| Accession Number: | Q9WTW1 |
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| Protein Name: | Glutamate receptor-interacting protein 2 |
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| Length: | 1043 |
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| Molecular Weight: | 112488.00 |
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| Species: | Rattus norvegicus (Rat) [10116] |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Peripheral membrane protein2 |
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| Substrate |
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1: MLAVSLKWRL GVVRRRPKDD GPYSKGGKDT AGTDGALVCR RQSIPEEFRG ITMVELIKRE
61: GSTLGLTISG GTDKDGKPRV SNLRPGGLAA RSDLLNVGDY IRSVNGIRLT RLRHDEIITL
121: LKNVGERVVL EVEYELPPPA PENNPRIISK TVDVSLYKEG NSFGFVLRGG AHEDLHKSRP
181: LVLTYVRPGG PADREGSLKV GDRLLSIDGI PLHGASHATA IATLQQCSHE ALFQVEYDVA
241: TPDTVANASG PLVVEIAKTP GSALGISLTT GSHRNKPAIT IDRIKPASVV DRSGALHAGD
301: HILAIDGTST EHCSLVEATK LLASVTEKVR LEILPAPQSR RPLKPPEAVR IQRSEQLHHW
361: DPCVPSCHSP RPSHCRAPTW APGGQDQSRS VSSTPFSSPT MNPAFPCANA STLPRGPMSP
421: RTTAGRRRQR RKEHRSSLSL ASSTVGPGGQ IVHTETTEVV LCGDPLSGFG LQLQGGIFAT
481: ETLSSPPLVR FIEPDSPAER CGLLQVGDRV LAINGIATED GTMEEANQLL RDAALARKVV
541: LEIEFDVAES VIPSSGTFHV KLPKRRGVEL GITISSASRK RGEPLIISDI KKGSVAHRTG
601: TLEPGDKLLA IDNIRLDHCP MEYAVQILRQ CEDLVKLKIR KDEDNSDEQE SSGAVSYTVE
661: LKRYGGPLGI TISGTEEPFD PIIISGLTKR GLAERTGAIH VGDRILAINS VSLKGRPLSE
721: AIHLLQVAGE TVTLKIKKQL DRPLLPRQSG SLSEASDVDE DPPEALKGGL LTTHFSPAVP
781: SVDSAVESWG SSATEGGFGG SGSYTPQVAV RSVTPQEWRS SRLKSSPPPL EPRRTSYTPG
841: PTDESFPEEE EGDWEPPMSP APGPAREEGF WRVLGEALED LESCGQSELL RELEASIMTG
901: TVQSVAVDGR PGSRPWRRSR EVGTSPEDLQ ELLLPTPLEM HRVTLHKDPV RNDFGFSVSD
961: GLLEKGVYVH TVRIDGPAQH GGLQPFDRLL QVNHVRTRDF DCCLAVPLLA EAGDILELVV
1021: SRNPLAQSRR TPGAPGPSSP QMI