8.A.24.2.1
Syntenin-1, SDCBP, of 298 aas and 1 C-terminal TMS, is also called syndecan binding protein-1, scaffold protein Pbp1, and melanoma differentiation-associated protein 9 (MDA-9) (Mitsou et al. 2017). Multifunctional adapter protein involved in a diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (Philley et al. 2016). Syndecans can regulate stretch-activated ion channels. The structure and function of the syndecans have been reviewed (Mitsou et al. 2017). ESCRT-to-membrane coupling via ALIX/syntenin/syndecan-4 is required for completion of cytokinesis (Addi et al. 2020).