8.A.24.2.3
Amyloid-beta A4 precursor protein-binding family A member 2, APBA2 or Mint2, of 749 aas and 3 or more C-terminal TMSs. Mint1 and 2, of the X11 protein family, are multidomain proteins composed of a conserved
PTB domain and two C-terminal PDZ domains. They are involved in
formation of multiprotein complexes, and two of the family members,
X11alpha and X11beta, are expressed primarily in neurons. Through interactions
with other neuronal proteins, they may modulate processing of APP and accumulation of
Abeta (Rogelj et al. 2006).
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| Accession Number: | Q99767 |
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| Protein Name: | Amyloid-beta A4 precursor protein-binding family A member 2 |
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| Length: | 749 |
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| Molecular Weight: | 82512.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Substrate |
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1: MAHRKLESVG SGMLDHRVRP GPVPHSQEPE SEDMELPLEG YVPEGLELAA LRPESPAPEE
61: QECHNHSPDG DSSSDYVNNT SEEEDYDEGL PEEEEGITYY IRYCPEDDSY LEGMDCNGEE
121: YLAHSAHPVD TDECQEAVEE WTDSAGPHPH GHEAEGSQDY PDGQLPIPED EPSVLEAHDQ
181: EEDGHYCASK EGYQDYYPEE ANGNTGASPY RLRRGDGDLE DQEEDIDQIV AEIKMSLSMT
241: SITSASEASP EHGPEPGPED SVEACPPIKA SCSPSRHEAR PKSLNLLPEA KHPGDPQRGF
301: KPKTRTPEER LKWPHEQVCN GLEQPRKQQR SDLNGPVDNN NIPETKKVAS FPSFVAVPGP
361: CEPEDLIDGI IFAANYLGST QLLSERNPSK NIRMMQAQEA VSRVKRMQKA AKIKKKANSE
421: GDAQTLTEVD LFISTQRIKV LNADTQETMM DHALRTISYI ADIGNIVVLM ARRRMPRSAS
481: QDCIETTPGA QEGKKQYKMI CHVFESEDAQ LIAQSIGQAF SVAYQEFLRA NGINPEDLSQ
541: KEYSDIINTQ EMYNDDLIHF SNSENCKELQ LEKHKGEILG VVVVESGWGS ILPTVILANM
601: MNGGPAARSG KLSIGDQIMS INGTSLVGLP LATCQGIIKG LKNQTQVKLN IVSCPPVTTV
661: LIKRPDLKYQ LGFSVQNGII CSLMRGGIAE RGGVRVGHRI IEINGQSVVA TAHEKIVQAL
721: SNSVGEIHMK TMPAAMFRLL TGQETPLYI