8.A.24.3.1
PRKCA-binding protein, PICK1, of 229 aas and possibly one TMS near the N-terminus. It is a probable adapter protein that binds to and organizes
the subcellular localization of a variety of membrane proteins
containing PDZ recognition sequences. It is involved in the clustering of
various receptors, possibly by acting at the receptor internalization
level. It plays a role in synaptic plasticity by regulating the trafficking
and internalization of AMPA receptors and may be regulated upon PRKCA
activation. It may regulate ASIC1/ASIC3 channels.
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| Accession Number: | F6V107 |
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| Protein Name: | PRKCA-binding protein |
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| Length: | 229 |
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| Molecular Weight: | 25092.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cell junction1 |
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| Substrate |
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1: MFADLDYDIE EDKLGIPTVP GKVTLQKDAQ NLIGISIGGG AQYCPCLYIV QVFDNTPAAL
61: DGTVAAGDEI TGVNGRSIKG KTKVEVAKMI QEVKGEVTIH YNKLQADPKQ GMSLDIVLKK
121: VKHRLVENMS SGTADALGLS RAILCNDGLV KRLEELERTA ELYKGMTEHT KNLLRAFYEL
181: SQTHRAFGDV FSVIGVREPQ PAASEAFVKF ADAHRSIEKF GIRLLKTIK