8.A.241.1.1
Hypoxia-inducible factor-1, α-subunit, HIF1α of 826 aas and from 0 to about 2 possible TMSs. The structure and functions have been considered (Iyer et al. 1998). This protein may regulate L-type Ca2+ channels in response to hypoxia (see family description (Moreno-Domínguez et al. 2024). It functions as a master transcriptional regulator of the adaptive response to hypoxia (Xu et al. 2018). Under
hypoxic conditions, it activates the transcription of over 40 genes,
including erythropoietin, glucose transporters, glycolytic enzymes,
vascular endothelial growth factor, HILPDA, and other genes whose
protein products increase oxygen delivery or facilitate metabolic
adaptation to hypoxia (Xu et al. 2018).
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| Accession Number: | AAC68568.1 |
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| Protein Name: | AAC68568.1 hypoxia-inducible factor 1 alpha subunit [Homo sapiens] |
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| Length: | 827 |
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| Molecular Weight: | |
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| Species: | Homo sapiens [9606] |
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| Number of TMSs: | 1 |
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| Substrate |
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1: MEGAGGANDK KKISSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV SSHLDKASVM
61: RLTISYLRVR KLLDAGDLDI EDDMKAQMNC FYLKALDGFV MVLTDDGDMI YISDNVNKYM
121: GLTQFELTGH SVFDFTHPCD HEEMREMLTH RNGLVKKGKE QNTQRSFFLR MKCTLTSRGR
181: TMNIKSATWK VLHCTGHIHV YDTNSNQPQC GYKKPPMTCL VLICEPIPHP SNIEIPLDSK
241: TFLSRHSLDM KFSYCDERIT ELMGYEPEEL LGRSIYEYYH ALDSDHLTKT HHDMFTKGQV
301: TTGQYRMLAK RGGYVWVETQ ATVIYNTKNS QPQCIVCVNY VVSGIIQHDL IFSLQQTECV
361: LKPVESSDMK MTQLFTKVES EDTSSLFDKL KKEPDALTLL APAAGDTIIS LDFGSNDTET
421: DDQQLEEVPL YNDVMLPSPN EKLQNINLAM SPLPTAETPK PLRSSADPAL NQEVALKLEP
481: NPESLELSFT MPQIQDQTPS PSDGSTRQSS PEPNSPSEYC FYVDSDMVNE FKLELVEKLF
541: AEDTEAKNPF STQDTDLDLE MLAPYIPMDD DLQLRSFDQL SPLESSSASP ESASPQSTVT
601: VFQQTQIQEP TANATTTTAT TDELKTVTKD RMEDIKILIA SPSPTHIHKE TTSATSSPYR
661: DTQSRTASPN RAGKGVIEQT EKSHPRSPNV LSVALSQRTT VPEEELNPKI LALQNAQRKR
721: KMEHDGSLFQ AVGIGTLLQQ PDDHAATTSL SWKRVKGCKS SEQNGMEQKT IILIPSDLAC
781: RLLGQSMDES GLPQLTSYDC EVNAPIQGSR NLLQGEELLR ALDQVN