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8.A.25.1.1
Ezrin of 586 aas and 0 TMSs. It is probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, it is required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, it is required for normal macropinocytosis.  A head-to-tail association, of the N-terminal and C-terminal halves, results in a closed conformation (inactive form) which is incapable of actin or membrane-binding (Matsui et al. 1998).

Accession Number:P26040
Protein Name:Ezrin aka p81 aka Cytovillin aka Villin-2
Length:586
Molecular Weight:69407.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Apical cell membrane1 / Peripheral membrane protein2 / Cytoplasmic side3
Substrate

Cross database links:

RefSeq: NP_033536.2    XP_001471687.1   
Entrez Gene ID: 100044177    22350   
Pfam: PF00769    PF09380    PF00373    PF09379   
KEGG: mmu:100044177    mmu:22350   

Gene Ontology

GO:0005884 C:actin filament
GO:0016324 C:apical plasma membrane
GO:0005938 C:cell cortex
GO:0019898 C:extrinsic to membrane
GO:0005932 C:microtubule basal body
GO:0031528 C:microvillus membrane
GO:0032587 C:ruffle membrane
GO:0001931 C:uropod
GO:0051015 F:actin filament binding
GO:0050839 F:cell adhesion molecule binding
GO:0051017 P:actin filament bundle assembly
GO:0035088 P:establishment or maintenance of apical/basa...
GO:0008360 P:regulation of cell shape

References (4)

[1] “Radixin is a novel member of the band 4.1 family.”  Funayama N.et.al.   1955455
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[4] “Characterization of the NF2 protein merlin and the ERM protein ezrin in human, rat, and mouse central nervous system.”  Groenholm M.et.al.   15797715

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR EVWYFGLQYV DNKGFPTWLK 
61:	LDKKVSAQEV RKENPVQFKF RAKFYPEDVA EELIQDITQK LFFLQVKDGI LSDEIYCPPE 
121:	TAVLLGSYAV QAKFGDYNKE MHKSGYLSSE RLIPQRVMDQ HKLSRDQWED RIQVWHAEHR 
181:	GMLKDSAMLE YLKIAQDLEM YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPKIGF 
241:	PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI LQLCMGNHEL YMRRRKPDTI 
301:	EVQQMKAQAR EEKHQKQLER QQLETEKKRR ETVEREKEQM LREKEELMLR LQDYEQKTKR 
361:	AEKELSEQIE KALQLEEERR RAQEEAERLE ADRMAALRAK EELERQAQDQ IKSQEQLAAE 
421:	LAEYTAKIAL LEEARRRKED EVEEWQHRAK EAQDDLVKTK EELHLVMTAP PPPPPPVYEP 
481:	VNYHVQEGLQ DEGAEPMGYS AELSSEGILD DRNEEKRITE AEKNERVQRQ LLTLSNELSQ 
541:	ARDENKRTHN DIIHNENMRQ GRDKYKTLRQ IRQGNTKQRI DEFEAM