8.A.25.1.3
Merlin, Mer, EMR2, of 635 aas and 1 TMS. Mer acts synergistically along with Ex and Kibra to regulate the Hippo signaling pathway (Yu et al. 2010). Merlin and Expanded (Q07436; 1,427 aas) function synergistically to control proliferation by regulating the abundance, localization, and turnover of cell-surface receptors (Maitra et al. 2006).
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| Accession Number: | Q24564 |
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| Protein Name: | Moesin/ezrin/radixin homolog 2 |
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| Length: | 635 |
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| Molecular Weight: | 74492.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Cell junction1 |
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| Substrate |
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1: MSPFGSKKNR SLSVRVSTFD SELEFKLEPR ASGQDLFDLV CRTIGLRESW YFGLQYVDTR
61: SNVSWLKMEK RVRDQRVELH ASNNVYVFSF YAKFFPENVS EELIQEITQH LFFLQVKQSI
121: LSMDIYCRPE ASVLLASYAV HVQYGPYDYE TYKDGMLAGG ELLPKGVTDQ YQMTPEMWEE
181: RIKTWYMDHE PMTRDEVEME YLKIAQDLDM YGVNYFPITN KNKTKLWLGV TSVGLNIYDE
241: RDKLTPKTTF QWNEIRHVSF DDKKFTIRLV DAKVSNFIFY SQDLHINKMI LDLCKGNHDL
301: YMRRRKPDTM EIQQMKAQAK EEKQRRQIER KKFIREKKLR EKAEHERYEL EKSMEHLQNE
361: MRMANDALRR SEETKELYFE KSRVNEEQMQ LTECKANHFK TEMDRLRERQ MKIEREKHDL
421: EKKIRDADFY VHQLTVENDK REAETEKLRK ELICAKMAER EATARLLEFL NSGRKSSTDS
481: LLTASSVSHA ANTASSMAAI STPSLITSSS TNDLETAGGA ELTTHSSHYL VQGDNSSGIS
541: DDFEPKEFIL TDNEMEQITN EMERNHLDYL RNSKQVQSQL QTLRSEIAPH KIEENQSNLD
601: ILSEAQIKAG ENKYSTLKKL KSGSTKARVA FFEEL