8.A.25.1.8
Fermitin-1, Fermt1 (or Kindlerin or Kindlin (KIND or URP1), of 677 aas with one N-terminal TMS + two possible TMSs within the first 120 aas, and another possible TMS at the C-terminus. It is involved in cell adhesion and contributes to integrin activation. When
coexpressed with talin (see 8.A.25.1.6/7), it potentiates activation of ITGA2B and is required for
normal keratinocyte proliferation. It is required for normal polarization of
basal keratinocytes in skin and for normal cell shape. It is required for
normal adhesion of keratinocytes to fibronectin and laminin, and for
normal keratinocyte migration to wound sites. It may also mediate TGF-beta 1
signaling in tumor progression (Kloeker et al. 2004). Talin and kindlin cooperate to control the density of integrin clusters (Pernier et al. 2023).
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| Accession Number: | Q9BQL6 |
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| Protein Name: | Fermitin family homolog 1 |
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| Length: | 677 |
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| Molecular Weight: | 77437.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MLSSTDFTFA SWELVVRVDH PNEEQQKDVT LRVSGDLHVG GVMLKLVEQI NISQDWSDFA
61: LWWEQKHCWL LKTHWTLDKY GVQADAKLLF TPQHKMLRLR LPNLKMVRLR VSFSAVVFKA
121: VSDICKILNI RRSEELSLLK PSGDYFKKKK KKDKNNKEPI IEDILNLESS PTASGSSVSP
181: GLYSKTMTPI YDPINGTPAS STMTWFSDSP LTEQNCSILA FSQPPQSPEA LADMYQPRSL
241: VDKAKLNAGW LDSSRSLMEQ GIQEDEQLLL RFKYYSFFDL NPKYDAVRIN QLYEQARWAI
301: LLEEIDCTEE EMLIFAALQY HISKLSLSAE TQDFAGESEV DEIEAALSNL EVTLEGGKAD
361: SLLEDITDIP KLADNLKLFR PKKLLPKAFK QYWFIFKDTS IAYFKNKELE QGEPLEKLNL
421: RGCEVVPDVN VAGRKFGIKL LIPVADGMNE MYLRCDHENQ YAQWMAACML ASKGKTMADS
481: SYQPEVLNIL SFLRMKNRNS ASQVASSLEN MDMNPECFVS PRCAKRHKSK QLAARILEAH
541: QNVAQMPLVE AKLRFIQAWQ SLPEFGLTYY LVRFKGSKKD DILGVSYNRL IKIDAATGIP
601: VTTWRFTNIK QWNVNWETRQ VVIEFDQNVF TAFTCLSADC KIVHEYIGGY IFLSTRSKDQ
661: NETLDEDLFH KLTGGQD