8.A.252.1.1
Heme oxidase 1 of 288 aas and one C-terminal TMS. Dracorhodin perochlorate sensitizes colorectal cancer to ferroptosis by activating HMOX1 and inhibiting the SLC7A11/GPX4 axis (Niu et al. 2025).
|
| Accession Number: | P09601 |
|---|
| Protein Name: | Heme oxygenase 1 |
|---|
| Length: | 288 |
|---|
| Molecular Weight: | 32819.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Single-pass type IV membrane protein2 / Cytoplasmic side3 |
|---|
| Substrate |
ferroheme b |
|---|
1: MERPQPDSMP QDLSEALKEA TKEVHTQAEN AEFMRNFQKG QVTRDGFKLV MASLYHIYVA
61: LEEEIERNKE SPVFAPVYFP EELHRKAALE QDLAFWYGPR WQEVIPYTPA MQRYVKRLHE
121: VGRTEPELLV AHAYTRYLGD LSGGQVLKKI AQKALDLPSS GEGLAFFTFP NIASATKFKQ
181: LYRSRMNSLE MTPAVRQRVI EEAKTAFLLN IQLFEELQEL LTHDTKDQSP SRAPGLRQRA
241: SNKVQDSAPV ETPRGKPPLN TRSQAPLLRW VLTLSFLVAT VAVGLYAM