8.A.28.1.7
SH3 and multiple ankyrin repeat domains protein 3, SHANK3, or Proline-rich synapse-associated protein 2, PSAP2 or PROSAP2, of 1731 aas. It is a major scaffold postsynaptic density protein which interacts with multiple proteins and complexes. Interconnects receptors of the postsynaptic
membrane including NMDA-type and metabotropic glutamate receptors via
complexes with GKAP/PSD-95 and HOMER, respectively (Shcheglovitov et al. 2013). SHANK is regulated epigenetically and interacts with GluR1. It is a monogentic cause of autism (ASD) and schizophrenia (Monteiro and Feng 2017).
|
| Accession Number: | Q9BYB0 |
|---|
| Protein Name: | SH3 and multiple ankyrin repeat domains protein 3 |
|---|
| Length: | 1731 |
|---|
| Molecular Weight: | 184667.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Number of TMSs: | 1 |
|---|
| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
|---|
| Substrate |
|
|---|
1: MDGPGASAVV VRVGIPDLQQ TKCLRLDPAA PVWAAKQRVL CALNHSLQDA LNYGLFQPPS
61: RGRAGKFLDE ERLLQEYPPN LDTPLPYLEF RYKRRVYAQN LIDDKQFAKL HTKANLKKFM
121: DYVQLHSTDK VARLLDKGLD PNFHDPDSGE CPLSLAAQLD NATDLLKVLK NGGAHLDFRT
181: RDGLTAVHCA TRQRNAAALT TLLDLGASPD YKDSRGLTPL YHSALGGGDA LCCELLLHDH
241: AQLGITDENG WQEIHQACRF GHVQHLEHLL FYGADMGAQN ASGNTALHIC ALYNQESCAR
301: VLLFRGANRD VRNYNSQTAF QVAIIAGNFE LAEVIKTHKD SDVVPFRETP SYAKRRRLAG
361: PSGLASPRPL QRSASDINLK GEAQPAASPG PSLRSLPHQL LLQRLQEEKD RDRDADQESN
421: ISGPLAGRAG QSKISPSGPG GPGPAPGPGP APPAPPAPPP RGPKRKLYSA VPGRKFIAVK
481: AHSPQGEGEI PLHRGEAVKV LSIGEGGFWE GTVKGRTGWF PADCVEEVQM RQHDTRPETR
541: EDRTKRLFRH YTVGSYDSLT SHSDYVIDDK VAVLQKRDHE GFGFVLRGAK AETPIEEFTP
601: TPAFPALQYL ESVDVEGVAW RAGLRTGDFL IEVNGVNVVK VGHKQVVALI RQGGNRLVMK
661: VVSVTRKPEE DGARRRAPPP PKRAPSTTLT LRSKSMTAEL EELASIRRRK GEKLDEMLAA
721: AAEPTLRPDI ADADSRAATV KQRPTSRRIT PAEISSLFER QGLPGPEKLP GSLRKGIPRT
781: KSVGEDEKLA SLLEGRFPRS TSMQDPVREG RGIPPPPQTA PPPPPAPYYF DSGPPPAFSP
841: PPPPGRAYDT VRSSFKPGLE ARLGAGAAGL YEPGAALGPL PYPERQKRAR SMIILQDSAP
901: ESGDAPRPPP AATPPERPKR RPRPPGPDSP YANLGAFSAS LFAPSKPQRR KSPLVKQLQV
961: EDAQERAALA VGSPGPGGGS FAREPSPTHR GPRPGGLDYG AGDGPGLAFG GPGPAKDRRL
1021: EERRRSTVFL SVGAIEGSAP GADLPSLQPS RSIDERLLGT GPTAGRDLLL PSPVSALKPL
1081: VSGPSLGPSG STFIHPLTGK PLDPSSPLAL ALAARERALA SQAPSRSPTP VHSPDADRPG
1141: PLFVDVQARD PERGSLASPA FSPRSPAWIP VPARREAEKV PREERKSPED KKSMILSVLD
1201: TSLQRPAGLI VVHATSNGQE PSRLGGAEEE RPGTPELAPA PMQSAAVAEP LPSPRAQPPG
1261: GTPADAGPGQ GSSEEEPELV FAVNLPPAQL SSSDEETREE LARIGLVPPP EEFANGVLLA
1321: TPLAGPGPSP TTVPSPASGK PSSEPPPAPE SAADSGVEEA DTRSSSDPHL ETTSTISTVS
1381: SMSTLSSESG ELTDTHTSFA DGHTFLLEKP PVPPKPKLKS PLGKGPVTFR DPLLKQSSDS
1441: ELMAQQHHAA SAGLASAAGP ARPRYLFQRR SKLWGDPVES RGLPGPEDDK PTVISELSSR
1501: LQQLNKDTRS LGEEPVGGLG SLLDPAKKSP IAAARLFSSL GELSSISAQR SPGGPGGGAS
1561: YSVRPSGRYP VARRAPSPVK PASLERVEGL GAGAGGAGRP FGLTPPTILK SSSLSIPHEP
1621: KEVRFVVRSV SARSRSPSPS PLPSPASGPG PGAPGPRRPF QQKPLQLWSK FDVGDWLESI
1681: HLGEHRDRFE DHEIEGAHLP ALTKDDFVEL GVTRVGHRMN IERALRQLDG S